Endocrinology and Metabolism

Hyo Sun Lee (Lee HS)

2 Articles

Clinical Study
The Relationship between 10-Year Cardiovascular Risk Calculated Using the Pooled Cohort Equation and the Severity of Non-Alcoholic Fatty Liver Disease: Jeong In Lee, Min Chul Kim, Byung Sub Moon, Young Seok Song, Eun Na Han, Hyo Sun Lee, Yoonjeong Son, Jihyun Kim, Eun Jin Han, Hye-Jeong Park, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee; Endocrinol Metab. 2016;31(1):86-92. Published online March 16, 2016; DOI: https://doi.org/10.3803/EnM.2016.31.1.86

4,755 View
40 Download
21 Web of Science
23 Crossref

Background

We investigated the association between the severity of non-alcoholic fatty liver disease (NAFLD) and the estimated 10-year risk of cardiovascular disease (CVD) calculated by Pooled Cohort Equation (PCE) and Framingham risk score (FRS).

Methods

A total of 15,913 participants (mean age, 46.3 years) in a health screening program were selected for analysis. The presence and severity of fatty liver was assessed by abdominal ultrasonogram. Subjects who drank alcohol more than three times a week were excluded from the study.

Results

Among the participants, 57.6% had no NAFLD, 35.4% had grade I, 6.5% had grade II, and 0.5% had grade III NAFLD. Mean estimated 10-year CVD risk was 2.59%, 3.93%, 4.68%, and 5.23% calculated using the PCE (P for trend <0.01) and 4.55%, 6.39%, 7.33%, and 7.13% calculated using FRS, according to NAFLD severity from none to severe (P for trend <0.01). The odds ratio for ≥7.5% estimated CVD risk calculated using the PCE showed a higher correlation with increasing severity of NAFLD even after adjustment for conventional CVD risk factors (1.52, 2.56, 3.35 vs. the no NAFLD group as a reference, P<0.01) compared with calculated risk using FRS (1.65, 1.62, 1.72 vs. no NAFLD group as a reference, P<0.01).

Conclusion

In our study of apparently healthy Korean adults, increasing severity of NAFLD showed a higher correlation with estimated 10-year CVD risk when calculated using the PCE than when calculated using FRS.

Citations

Citations to this article as recorded by

Nonalcoholic Fatty Liver Disease Increases Cardiovascular Risk in Inflammatory Bowel Diseases
Dana Kablawi, Faisal Aljohani, Chiara Saroli Palumbo, Sophie Restellini, Alain Bitton, Gary Wild, Waqqas Afif, Peter L Lakatos, Talat Bessissow, Giada Sebastiani
Crohn's & Colitis 360.2023;[Epub] CrossRef
Low Relative Handgrip Strength Is Associated with a High Risk of Non-Alcoholic Fatty Liver Disease in Italian Adults: A Retrospective Cohort Study
Samantha Maurotti, Roberta Pujia, Elisa Mazza, Maria Francesca Pileggi, Franco Arturi, Maria Grazia Tarsitano, Tiziana Montalcini, Arturo Pujia, Yvelise Ferro
Applied Sciences.2023; 13(22): 12489. CrossRef
Fatty Liver Disease: Diagnosis and Stratification
Yedidya Saiman, Andres Duarte-Rojo, Mary E. Rinella
Annual Review of Medicine.2022; 73(1): 529. CrossRef
“Dangerous liaisons: NAFLD and liver fibrosis increase cardiovascular risk in HIV”
Adriana Cervo, Giada Sebastiani, Jovana Milic, Thomas Krahn, Sergio Mazzola, Salvatore Petta, Antonio Cascio, Giovanni Guaraldi, Giovanni Mazzola
HIV Medicine.2022; 23(8): 911. CrossRef
Value of the triglyceride glucose index combined with body mass index in identifying non-alcoholic fatty liver disease in patients with type 2 diabetes
Nong Li, Huiwen Tan, Aixia Xie, Cheng Li, Xuan Fu, Weiting Xang, Amina Kirim, Xuefang Huang
BMC Endocrine Disorders.2022;[Epub] CrossRef
The Relation Between Non-alcoholic Fatty Liver Disease and the Risk of Coronary Heart Disease
Seyed Moayed Alavian, Hosein Zadi
Multidisciplinary Cardiovascular Annals.2022;[Epub] CrossRef
Risk factors for cardiovascular disease among individuals with hepatic steatosis
Julia Karády, Maros Ferencik, Thomas Mayrhofer, Nandini M. Meyersohn, Daniel O. Bittner, Pedro V. Staziaki, Balint Szilveszter, Travis R. Hallett, Michael T. Lu, Stefan B. Puchner, Tracey G. Simon, Borek Foldyna, Geoffrey S. Ginsburg, Robert W. McGarrah,
Hepatology Communications.2022; 6(12): 3406. CrossRef
Triglyceride Glucose Index and Related Parameters (Triglyceride Glucose-Body Mass Index and Triglyceride Glucose-Waist Circumference) Identify Nonalcoholic Fatty Liver and Liver Fibrosis in Individuals with Overweight/Obesity
Mohammad E. Khamseh, Mojtaba Malek, Rowshanak Abbasi, Hoda Taheri, Maryam Lahouti, Fariba Alaei-Shahmiri
Metabolic Syndrome and Related Disorders.2021; 19(3): 167. CrossRef
Interplay between non‐alcoholic fatty liver disease and cardiovascular risk in an asymptomatic general population
Grazia Pennisi, Vito Di Marco, Carola Buscemi, Giovanni Mazzola, Cristiana Randazzo, Federica Spatola, Antonio Craxì, Silvio Buscemi, Salvatore Petta
Journal of Gastroenterology and Hepatology.2021; 36(9): 2389. CrossRef
Non-Laboratory-Based Simple Screening Model for Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes Developed Using Multi-Center Cohorts
Jiwon Kim, Minyoung Lee, Soo Yeon Kim, Ji-Hye Kim, Ji Sun Nam, Sung Wan Chun, Se Eun Park, Kwang Joon Kim, Yong-ho Lee, Joo Young Nam, Eun Seok Kang
Endocrinology and Metabolism.2021; 36(4): 823. CrossRef
Coronary Artery Disease is More Severe in Patients with Non-Alcoholic Steatohepatitis than Fatty Liver
Toshihiro Niikura, Kento Imajo, Anna Ozaki, Takashi Kobayashi, Michihiro Iwaki, Yasushi Honda, Takaomi Kessoku, Yuji Ogawa, Masato Yoneda, Hiroyuki Kirikoshi, Satoru Saito, Atsushi Nakajima
Diagnostics.2020; 10(3): 129. CrossRef
Cardiovascular Disease in Nonalcoholic Steatohepatitis: Screening and Management
Hersh Shroff, Lisa B. VanWagner
Current Hepatology Reports.2020; 19(3): 315. CrossRef
Triglyceride Glucose Index Is Superior to the Homeostasis Model Assessment of Insulin Resistance for Predicting Nonalcoholic Fatty Liver Disease in Korean Adults
Sang Bae Lee, Min Kyung Kim, Shinae Kang, Kahui Park, Jung Hye Kim, Su Jung Baik, Ji Sun Nam, Chul Woo Ahn, Jong Suk Park
Endocrinology and Metabolism.2019; 34(2): 179. CrossRef
Mortality Risk Detected by Atherosclerotic Cardiovascular Disease Score in Patients With Nonalcoholic Fatty Liver Disease
Pegah Golabi, Natsu Fukui, James Paik, Mehmet Sayiner, Alita Mishra, Zobair M. Younossi
Hepatology Communications.2019; 3(8): 1050. CrossRef
Lower hand grip strength in older adults with non-alcoholic fatty liver disease: a nationwide population-based study
Beom-Jun Kim, Seong Hee Ahn, Seung Hun Lee, Seongbin Hong, Mark W. Hamrick, Carlos M. Isales, Jung-Min Koh
Aging.2019; 11(13): 4547. CrossRef
Implication of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, and Subclinical Inflammation on Mild Renal Insufficiency
Ga Eun Nam, Soon Young Hwang, Hye Soo Chung, Ju Hee Choi, Hyun Jung Lee, Nam Hoon Kim, Hye Jin Yoo, Ji-A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi
International Journal of Endocrinology.2018; 2018: 1. CrossRef
Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study
Kyung Mook Choi, Kyungdo Han, Sanghyun Park, Hye Soo Chung, Nam Hoon Kim, Hye Jin Yoo, Ji-A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Yong Gyu Park, Seon Mee Kim
Scientific Reports.2018;[Epub] CrossRef
Controlled Attenuation Parameter as a Noninvasive Method to Detect and Quantify Hepatic Steatosis in Chronic Liver Disease: What Is the Clinical Relevance
Mariana Verdelho Machado
GE - Portuguese Journal of Gastroenterology.2017; 24(4): 157. CrossRef
Effect of statin on hepatocellular carcinoma in patients with type 2 diabetes: A nationwide nested case‐control study
Gyuri Kim, Suk‐Yong Jang, Eugene Han, Yong‐ho Lee, Se‐young Park, Chung Mo Nam, Eun Seok Kang
International Journal of Cancer.2017; 140(4): 798. CrossRef
Clinical Characteristics of Non-Alcoholic Fatty Liver Disease Based on Analyses from the Kangbuk Samsung Health Study
Eun-Jung Rhee
The Journal of Korean Diabetes.2017; 18(2): 81. CrossRef
Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation
Jihyun Kim, Da Young Lee, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee, Susanne Kaser
PLOS ONE.2017; 12(7): e0180118. CrossRef
Articles inEndocrinology and Metabolismin 2016
Won-Young Lee
Endocrinology and Metabolism.2017; 32(1): 62. CrossRef
Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases
Eugene Han, Yong-ho Lee
Diabetes & Metabolism Journal.2017; 41(6): 430. CrossRef

Clinical Study
Metabolic Health Is More Important than Obesity in the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Retrospective Study: Min-Kyung Lee, Eun-Jung Rhee, Min Chul Kim, Byung Sub Moon, Jeong In Lee, Young Seok Song, Eun Na Han, Hyo Sun Lee, Yoonjeong Son, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee; Endocrinol Metab. 2015;30(4):522-530. Published online December 31, 2015; DOI: https://doi.org/10.3803/EnM.2015.30.4.522

4,476 View
61 Download
23 Web of Science
23 Crossref

Abstract PDF PubReader

Background

The aim of this study is to compare the risk for future development of nonalcoholic fatty liver disease (NAFLD) according to different status of metabolic health and obesity.

Methods

A total of 3,045 subjects without NAFLD and diabetes at baseline were followed for 4 years. Subjects were categorized into four groups according to the following baseline metabolic health and obesity statuses: metabolically healthy, non-obese (MHNO); metabolically healthy, obese (MHO); metabolically unhealthy, non-obese (MUHNO); and metabolically unhealthy, obese (MUHO). Being metabolically healthy was defined as having fewer than two of the following five components: high blood pressure, high fasting blood glucose, high triglyceride, low high density lipoprotein cholesterol, and being in the highest decile of the homeostasis model assessment-insulin resistance index. Obesity was defined as a body mass index >25 kg/m². The presence of NAFLD was assessed by ultrasonography.

Results

The proportions of subjects included in the MHNO, MHO, MUHNO, and MUHO groups were 71.4%, 9.8%, 13.0%, and 5.8%, respectively. The proportions of subjects who developed NAFLD were 10.5%, 31.4%, 23.2%, and 42% in the MHNO, MHO, MUHNO, and MUHO groups, respectively. The risk for developing NAFLD was highest in subjects who were metabolically unhealthy both at baseline and after 4 years compared with subjects who were consistently metabolically healthy during the follow-up period (odds ratio, 2.862). Using the MHNO group as reference, the odds ratios for the MHO, MUHNO, and MUHO groups were 1.731, 1.877, and 2.501, respectively.

Conclusion

The risk for NAFLD was lower in MHO subjects than in MUNO subjects.

Citations

Citations to this article as recorded by

Increased metabolic variability in Korean patients with new onset bipolar disorder: a nationwide cohort study
Ji Hyun Baek, Kyungdo Han, Hyewon Kim, Kyojin Yang, Hong Jin Jeon
Frontiers in Psychiatry.2024;[Epub] CrossRef
Increased risk of incident atrial fibrillation in young adults with mental disorders: A nationwide population-based study
Hyun Jin Ahn, So-Ryoung Lee, Eue-Keun Choi, Nan Young Bae, Hyo-Jeong Ahn, Soonil Kwon, Seung-Woo Lee, Kyung-Do Han, Seil Oh, Gregory Y.H. Lip
Heart Rhythm.2023; 20(3): 365. CrossRef
Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis
Wolhwa Song, Sung Hwan Yoo, Jinsun Jang, Su Jung Baik, Byoung Kwon Lee, Hyun Woong Lee, Jong Suk Park
Gut and Liver.2023; 17(1): 130. CrossRef
The impact of metabolic health on non-alcoholic fatty liver disease (NAFLD). A single center experience
Anna Boulouta, Ioanna Aggeletopoulou, Stavros Kanaloupitis, Efthymios P Tsounis, Vasileios Issaris, Konstantinos Papantoniou, Anastasios Apostolos, Paraskevas Tsaplaris, Ploutarchos Pastras, Christos Sotiropoulos, Aggeliki Tsintoni, Georgia Diamantopoulou
Clinics and Research in Hepatology and Gastroenterology.2022; 46(5): 101896. CrossRef
Lean non-alcoholic fatty liver disease (Lean-NAFLD) and the development of metabolic syndrome: a retrospective study
Wenting Wang, Jianping Ren, Wenzhao Zhou, Jinyu Huang, Guomin Wu, Fenfang Yang, Shuang Yuan, Juan Fang, Jing Liu, Yao Jin, Haiyang Qi, Yuyang Miao, Yanna Le, Cenhong Ge, Xiantao Qiu, JinJing Wang, Ping Huang, Zixin Liu, Sheng Wang
Scientific Reports.2022;[Epub] CrossRef
Metabolically healthy obesity and risk of non‐alcoholic fatty liver disease severity independent of visceral fat
Tsung‐Po Chen, Wen‐Yuan Lin, Chien‐Hsieh Chiang, Ting‐Hsin Shen, Kuo‐Chin Huang, Kuen‐Cheh Yang
Journal of Gastroenterology and Hepatology.2021; 36(10): 2903. CrossRef
Increased metabolic variability is associated with newly diagnosed depression: A nationwide cohort study
Ji Hyun Baek, Dong Wook Shin, Maurizio Fava, David Mischoulon, Hyewon Kim, Mi Jin Park, Eun Ji Kim, Kyung-Do Han, Hong Jin Jeon
Journal of Affective Disorders.2021; 294: 786. CrossRef
The expression signatures in liver and adipose tissue from obese Göttingen Minipigs reveal a predisposition for healthy fat accumulation
Susanna Cirera, Emirhan Taşöz, Mette Juul Jacobsen, Camilla Schumacher-Petersen, Berit Østergaard Christoffersen, Rikke Kaae Kirk, Trine Pagh Ludvigsen, Henning Hvid, Henrik Duelund Pedersen, Lisbeth Høier Olsen, Merete Fredholm
Nutrition & Diabetes.2020;[Epub] CrossRef
Impact of obesity and metabolic health status in the development of non-alcoholic fatty liver disease (NAFLD): A United Kingdom population-based cohort study using the health improvement network (THIN)
A. Vusirikala, T. Thomas, N. Bhala, A. A. Tahrani, G. N. Thomas, K. Nirantharakumar
BMC Endocrine Disorders.2020;[Epub] CrossRef
Epidemiology of nonalcoholic fatty liver disease in non‐obese populations: Meta‐analytic assessment of its prevalence, genetic, metabolic, and histological profiles
Zi Yuan Zou, Vincent Wai‐Sun Wong, Jian Gao Fan
Journal of Digestive Diseases.2020; 21(7): 372. CrossRef
Ultrasound-Diagnosed Nonalcoholic Fatty Liver Disease Independently Predicts a Higher Risk of Developing Diabetes Mellitus in Nonoverweight Individuals
Liang Wang
Academic Radiology.2019; 26(7): 863. CrossRef
Blood Pressure and Development of Cardiovascular Disease in Koreans With Type 2 Diabetes Mellitus
Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
Hypertension.2019; 73(2): 319. CrossRef
Understanding the association of polycystic ovary syndrome and non-alcoholic fatty liver disease
Nicolás Salva-Pastor, Norberto C. Chávez-Tapia, Misael Uribe, Natalia Nuño-Lámbarri
The Journal of Steroid Biochemistry and Molecular Biology.2019; 194: 105445. CrossRef
Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study
Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
Cardiovascular Diabetology.2019;[Epub] CrossRef
Longitudinal analysis of risk of non‐alcoholic fatty liver disease in adulthood
Daniel J. Cuthbertson, Emily Brown, Juha Koskinen, Costan G. Magnussen, Nina Hutri‐Kähönen, Matthew Sabin, Päivi Tossavainen, Eero Jokinen, Tomi Laitinen, Jorma Viikari, Olli T. Raitakari, Markus Juonala
Liver International.2019; 39(6): 1147. CrossRef
Associations of Variability in Blood Pressure, Glucose and Cholesterol Concentrations, and Body Mass Index With Mortality and Cardiovascular Outcomes in the General Population
Mee Kyoung Kim, Kyungdo Han, Yong-Moon Park, Hyuk-Sang Kwon, Gunseog Kang, Kun-Ho Yoon, Seung-Hwan Lee
Circulation.2018; 138(23): 2627. CrossRef
The effects of metabolic status on non‐alcoholic fatty liver disease‐related outcomes, beyond the presence of obesity
Javier Ampuero, Rocío Aller, Rocío Gallego‐Durán, Jesus M. Banales, Javier Crespo, Carmelo García‐Monzón, María Jesús Pareja, Eduardo Vilar‐Gómez, Juan Caballería, Desamparados Escudero‐García, Judith Gomez‐Camarero, José Luis Calleja, Mercedes Latorre, A
Alimentary Pharmacology & Therapeutics.2018; 48(11-12): 1260. CrossRef
Dissecting the relationship between obesity and hyperinsulinemia: Role of insulin secretion and insulin clearance
Mee Kyoung Kim, Gerald M. Reaven, Sun H. Kim
Obesity.2017; 25(2): 378. CrossRef
The Effects of Exercise on Abdominal Fat and Liver Enzymes in Pediatric Obesity: A Systematic Review and Meta-Analysis
Katherine González-Ruiz, Robinson Ramírez-Vélez, Jorge Enrique Correa-Bautista, Mark D. Peterson, Antonio García-Hermoso
Childhood Obesity.2017; 13(4): 272. CrossRef
Clinical Characteristics of Non-Alcoholic Fatty Liver Disease Based on Analyses from the Kangbuk Samsung Health Study
Eun-Jung Rhee
The Journal of Korean Diabetes.2017; 18(2): 81. CrossRef
Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases
Eugene Han, Yong-ho Lee
Diabetes & Metabolism Journal.2017; 41(6): 430. CrossRef
Predictive Value of Triglyceride Glucose Index for the Risk of Incident Diabetes: A 4-Year Retrospective Longitudinal Study
Da Young Lee, Eun Seo Lee, Ji Hyun Kim, Se Eun Park, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee, Won-Young Lee, Fernando Guerrero-Romero
PLOS ONE.2016; 11(9): e0163465. CrossRef
Lean, but not healthy
Cherlyn Ding, Zhiling Chan, Faidon Magkos
Current Opinion in Clinical Nutrition & Metabolic Care.2016; 19(6): 408. CrossRef

Author index